The Harmison brothers, Stephen and Ben, shared six wickets as the Scots were dismissed for 192 in reply to 230 for six.
Despite bowling at a good 10mph below his brother’s pace, it was 22-year-old Ben who wrecked any Scottish hopes of a second win in the competition.
Coming on at 42 for two after 12 overs, it was not until his 28th ball that a run was scored off him when Neil McCallum lofted him over mid-off for four.
By that stage Ben had taken two wickets, having Colin Smith caught at slip and Ryan Watson at deep square leg.
Inbetween those dismissals Steve had Fraser Watts caught behind and with three wickets going down for five runs Scotland were doomed at 51 for five.
McCallum prevented Durham from making vital improvements to their run-rate by making a plucky 60 before Harmison senior yorked him.
Durham will be praying to win the toss on Monday after losing it in all seven matches so far, which meant they were again put in yesterday.
Michael Di Venuto hit two of the first three balls from John Blain for four, but in the ex-Yorkshire seamer’s next over the Tasmanian left-hander skied a return catch when attempting to pull.
Will Smith, preferred to Kyle Coetzer for his first appearance of the season, perished in the same manner.
Phil Mustard and Neil McKenzie put on 75, but the England one-day wicketkeeper again looked out of touch until the medium pace of Richie Berrington was introduced at 45 for two after 17 overs.
Mustard had struggled to 20 at that point, but hit the third ball wide of long on for six as 18 came off the over.
Five overs later Mustard had raced to a half-century, but he was run out for 57 when sent back at the non-striker’s end.
Dale Benkenstein then put on 70 in 12 overs with McKenzie before he went down the pitch in the 40th over and was bowled by left-arm spinner Glenn Rogers.
McKenzie had only two fours in his 82-ball half-century but quickly hit three more before edging Blain to wicketkeeper Colin Smith.
Scotland sent in Gavin Hamilton to open against the county where he ended his first-class career, but after lashing two fours he drove at Callum Thorp and edged to Mustard.